Proteomics seminar series for the South East
---Registration is free---
-- The London Proteomics Discussion Group --
Proteomics seminar series for the South East
Proteomics seminar series for the South East
We are a free, local proteomics seminar series in the South East,
with a focus towards networking, discussion and supporting early career researchers.
The LPDG...
was founded to bring together the large community of proteomics scientists all working in and around London. We aim to provide a space for discussion, with a focus on methods and early career researchers (two fundamental building blocks of good research!), on all topics related to proteomics. The meetings comprise of research talks framed by a proteomics methods challenge, lunch, refreshments and pizza - they are free to attend thanks to sponsorship.
Meeting Dates:
These seminars would not be possible without our amazing sponsors.
If you are interested in sponsoring an LPDG seminar,
please get in touch at sponsor@londonproteomics.co.uk
05th February 2021 14:00 GMT
Data-independent acquisition (DIA) method for systems-wide investigation of ubiquitin signaling
Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products (AGEs) has been shown to accumulate during aging and age-associated diseases but specific protein targets and functional consequences remain largely unexplored. Here, we devised a proteomic strategy to identify specific sites of carboxymethyllysine (CML) modification, one of the most abundant AGEs. We identified over 1000 sites of CML modification in mouse and primary human cells treated with the glycating agent glyoxal. By using quantitative proteomics, we found that protein glycation triggers a proteotoxic response and directly affects the protein degradation machinery. We show that glyoxal induces cell cycle perturbation in primary endothelial cells and that CML modification reduces acetylation of tubulins and impairs microtubule dynamics. Our data demonstrate the relevance of AGE modification for cellular function and pinpoint specific protein networks that might become compromised during aging.
Would you like to present at an LPDG meeting? Email: speaker@londonproteomics.co.uk
Research presentations from:
Özge Karayel completed her undergraduate and masters studies in Molecular Biology and Genetics and Biotechnology & Bioinformatics from Koç University in Istanbul, Turkey. She then joined the group of Professor Dr. Matthias Mann as a doctoral researcher at the Max Planck Institute of Biochemistry in Martinsried, Germany. She currently works in the same laboratory as a postdoctoral researcher. Her expertise lies in the field of mass spectrometry (MS)-based proteomics and her research interest is centered mainly on the development of sensitive and quantitative proteomics strategies to study phospho- and ubiquitin-signaling in health and disease.
Simone studied medical biotechnologies at the University of Milano-Bicocca, Italy and now he is completing his PhD at the Leibniz Institute on Aging - FLI, Jena, Germany. His doctoral work involves investigating PTMs, in particular Advanced Glycation End Products, during aging, by applying mass spectrometry-based proteomics.
Prof Tate was appointed Professor of Chemical Biology in 2014 and is a Fellow of both the Royal Society of Chemistry and the Royal Society of Biology. His research lies at the interface between organic chemistry, the life sciences and medicine, in the fields of chemical biology and chemical proteomics. The unifying theme of his work is the design and application of chemical approaches to understand and manipulate living systems, with an emphasis on processes important to disease.
March 2020 Meeting
Here is a list of answers to frequently asked questions for speakers, delegates and sponsors
The meetings are free to attend! We raise money through the generous support of sponsors for refreshments and venue hire. Sponsors are offered the opporunity to suggest a plenary research presentaiton or present a short (10min) sales talk.
Yes! Thanks again to the support of our sponsors, we are able to provide a sandwhich buffet lunch, refreshments, and pizza and drinks to end. We try our best to get a range of refreshments to support diverse dietry requirments, but please let us know in advance if you have any specific needs.
We are always looking for new speakers - from PhD candidates to senior scientists within proteomics. We recruit speakers through personal invitations/networking, suggestions from deligates and from people contacting us directly. If you would like to present at a meeting, we would be delighted to hear from you, please get in touch at speaker@londonproteomics.co.uk
Registration is not essential, but it is very helpful for us to arrange catering and venues to ensure we don't over/under spend. In some cases, where space is limiting, registration may be essential and we will advertise this. If in doubt - register!
We do not have any funding to support delegates. However, if you are speaking, it may be possible to get a travel grant from the British Society for Proteome Research (BSPR). In some instances, we may be able to subsidise travel costs for speakers, but this is dependant on sponsorship for that meeting.
The organising committee is made up of early career (including PhD candidates) and more experienced scientist from academia and industry. We are very keen to have a bredth of backgrounds and experience on the committee, so if you would like to be involved, please get in touch by speaking to a committee member at a meeting, or emailing us - we would like to hear from you!
Our meetings are focused on proteomics and the delegates include proteomics-users from academia and industry. Therefore, at these meetings, there is a "captured audience" of possible clients. Sponsoring our meeting will allow you to present your product or service to a concentrated group of possible users. These meetings are only possible with sponsorship, and you will be contributing to the disemiation of science, and potentially meeting tallented future employees through networking.
We have a range of options for meeting sponsorship. To sponsor a meeting, please get in touch at sponsor@londonproteomics.co.uk, we will be delighted to hear from you.
Yes! Just like our physical meetings, our webinars are completely free to attend.
Please register for our meeting in the normal way (click here). A link will be emailed to you prior to the meeting starting with instructions on how to join. Alternatively, a join link for the webinar will also be posted here immediately prior to it starting. For webinars run as a Microsoft Live Event, find instructions on how to join here, or using Zoom here.
The discussion will be mediated by the chairperson who will take questions from all attendies. The best way to contribute during the talk and to post questions is through our slack account.
The meetings are recored and will be posted to our archive page.
We do not currently recieve any funding for our webinars. We are able to put them on with the generous support of other institution who allow us to use their webinar-enabled online communications accounts (e.g. Zoom).
If you still have unanswered questions after reading this page, wish to present a talk, suggest a venue or sponsor a meeting, please contact us.
The organising committee is made up of early and "not-so-early" career scientists
from academia and industry.
If you are interested in joining the committee, please get in touch.
After my PhD in blood plasma cancer proteomics I moved to the Cancer Proteomics Group at UCL. I founded the LPDG as a focus group for the SE. I am currently at the Babraham Institute investigating protein degradation pathways using proteomics.
I am a post doc at ICL, developing mass spectrometry and data analysis methodology for the study of protein PTMs, in particular methylation. My research is multidisciplinary, using chemistry, bioinformatics and biology. For more info, click here.
I am a post-doc at the ICR in Paul Huang’s group. My research interest is in extracellular matrix remodelling during cancer progression. From an analytical point of view, I am interested in protein quantification by DIA mass spectrometry.
I manage an MS lab at QMUL. I graduated from Drexel University (USA) in Biomedical Science, completing my PhD work at Harvard University. After a long stint in the private sector, I re-joined academia here in the UK researching lipidomics and proteomics.
Danai studied biology and biomedical sciences in Greece. She has worked in numerous labs in England, Singapore, the Netherlands and Greece. Now she is focusing on her PhD at UCL in Primary Biliary Cholangitis analyzing human samples using Mass spectrometry.
I am a PhD student at UCL on the CellX project in the Thalassinos Lab studying competition in cellular populations using mass spectrometry-based proteomics.
Daniel is a post-doc in the lab of Prof. Ed Tate at Imperial College London. His research interests lie in the use of chemical proteomics for better understanding of drug targets, protein function, and post-translational modification dynamics.
Tom works for SCIEX in the London region helping customers with MS and 'OMICS applications. He gained an interest in MS from working with Prof Roy Goodacre, Manchester Institute of Biotech. applying -omics and chemometric approaches for rapid food authenticity determination.
Please email with any questions.
Particularly welcome are venue suggestions,
speaker suggestions or if you are thinking of sponsoring a meeting.
This seminar series is run by volunteers from academia and industry. We will try to reply to your email as quickly as possible, but please allow at least 5 days.
