Proteomics seminar series for the South East
---Registration is free---
-- The London Proteomics Discussion Group --
Proteomics seminar series for the South East
Proteomics seminar series for the South East
We are a free, local proteomics seminar series in the South East,
with a focus towards networking, discussion and supporting early career researchers.
The LPDG...
was founded to bring together the large community of proteomics scientists all working in and around London. We aim to provide a space for discussion, with a focus on methods and early career researchers (two fundamental building blocks of good research!), on all topics related to proteomics. The meetings comprise of research talks framed by a proteomics methods challenge, lunch, refreshments and pizza - they are free to attend thanks to sponsorship.
Meeting Dates:
These seminars would not be possible without our amazing sponsors.
If you are interested in sponsoring an LPDG seminar,
please get in touch at sponsor@londonproteomics.co.uk
18th June 2021 14:00 GMT
How Proteins and Metabolites Handshake: proteomics technologies for studying protein-small molecule intersactions
Different environmental cues such as stress, nutrients or drugs, trigger rapid adaptive responses that allow to maintain cellular homeostasis. One of the fastest cellular responses to the environment is the binding of small molecules to proteins. These molecular interactions produce allosteric effects, which means that they trigger a variation of protein activity as a consequence of a conformational change. Allosteric interactions are thus essential for life and can modulate both the metabolic status of the cells and gene expression. My group focuses on the development of new MS-bases proteomics technologies to study global structural changes in the proteome. In my talk I will describe the applications of a proteomic technique called LiP-MS to discover novel protein-metabolite interactions in bacteria and its more recent applications for the study of the protein small-molecule interactome in human cells.
Profiling the Proteome-Wide Selectivity of Diverse Electrophiles
Targeted covalent inhibitors (TCIs) have experienced a resurgence of interest for drug discovery applications as they can have key advantages such as increased binding affinity to the target and the possibility to generate selectivity among closely related proteins. Competitive residue-specific proteomics allows the streamlined identification of on- and off-targets of TCIs and thus aids the development of selective ligands. Since most TCIs so far address cysteine residues because of their inherent outstanding nucleophilicity, the number of potentially addressable proteins is significantly limited by the requirement for these rare reactive cysteines. While many electrophilic groups have been reported to engage other amino acids, their selectivity towards the proteome has hardly ever been assessed and differences in the experimental workflow and the data analysis make it impossible to directly compare different studies. To address these issues, we combined our recently developed isoDTB-ABPP platform with the FragPipe software suite into a universal and unbiased workflow that identifies the modification caused by a covalent alkyne probe and the sites it occurs on in a quantitative fashion. We analysed >50 such electrophiles and verified or newly identified probes to selectively monitor nine different amino acids and the N-terminus proteome-wide. This toolset will enable competitive profiling of TCIs against a variety of reactive amino acids and thereby guide the development of novel TCIs.
Would you like to present at an LPDG meeting? Email: speaker@londonproteomics.co.uk
Research presentations from:
Patrick Zanon has obtained his B.Sc. and M.Sc. in chemistry at the Technical University of Munich, where he is currently pursuing a PhD in the group of Dr. Stephan M. Hacker. Funded by a Liebig PhD fellowship by the Fonds der Chemischen Industrie, he developed the isoDTB-ABPP platform, which allows the residue-specific identification of the target proteins of covalent ligands. By applying this method to so far underexplored nucleophilic amino acids, he aims to expand the fraction of the proteome that is deemed “druggable”. This research is motivated by the need to identify lead compounds with new modes-of-action to combat antibiotic resistance.
My research started with my PhD studies at EMBL in Heidelberg, studying molecular machines regulating chromatin structure and gene expression during the cell cycle. After stumbling into crosslinking MS in the Beck laboratory, I studied protein structures in the Picotti laboratory at ETH Zurich. I developed a method that combines limited proteolysis and MS to characterise interactions between proteins and metabolites (LiP-SMap). The goal of my research as group leader is to study how metabolism regulates chromatin architecture and its impact on gene expression.
Coming soon!
March 2020 Meeting
Here is a list of answers to frequently asked questions for speakers, delegates and sponsors
The meetings are free to attend! We raise money through the generous support of sponsors for refreshments and venue hire. Sponsors are offered the opporunity to suggest a plenary research presentaiton or present a short (10min) sales talk.
Yes! Thanks again to the support of our sponsors, we are able to provide a sandwhich buffet lunch, refreshments, and pizza and drinks to end. We try our best to get a range of refreshments to support diverse dietry requirments, but please let us know in advance if you have any specific needs.
We are always looking for new speakers - from PhD candidates to senior scientists within proteomics. We recruit speakers through personal invitations/networking, suggestions from deligates and from people contacting us directly. If you would like to present at a meeting, we would be delighted to hear from you, please get in touch at speaker@londonproteomics.co.uk
Registration is not essential, but it is very helpful for us to arrange catering and venues to ensure we don't over/under spend. In some cases, where space is limiting, registration may be essential and we will advertise this. If in doubt - register!
We do not have any funding to support delegates. However, if you are speaking, it may be possible to get a travel grant from the British Society for Proteome Research (BSPR). In some instances, we may be able to subsidise travel costs for speakers, but this is dependant on sponsorship for that meeting.
The organising committee is made up of early career (including PhD candidates) and more experienced scientist from academia and industry. We are very keen to have a bredth of backgrounds and experience on the committee, so if you would like to be involved, please get in touch by speaking to a committee member at a meeting, or emailing us - we would like to hear from you!
Our meetings are focused on proteomics and the delegates include proteomics-users from academia and industry. Therefore, at these meetings, there is a "captured audience" of possible clients. Sponsoring our meeting will allow you to present your product or service to a concentrated group of possible users. These meetings are only possible with sponsorship, and you will be contributing to the disemiation of science, and potentially meeting tallented future employees through networking.
We have a range of options for meeting sponsorship. To sponsor a meeting, please get in touch at sponsor@londonproteomics.co.uk, we will be delighted to hear from you.
Yes! Just like our physical meetings, our webinars are completely free to attend.
Please register for our meeting in the normal way (click here). A link will be emailed to you prior to the meeting starting with instructions on how to join. Alternatively, a join link for the webinar will also be posted here immediately prior to it starting. For webinars run as a Microsoft Live Event, find instructions on how to join here, or using Zoom here.
The discussion will be mediated by the chairperson who will take questions from all attendies. The best way to contribute during the talk and to post questions is through our slack account.
The meetings are recored and will be posted to our archive page.
The webinars are put on with the generous support academic institutions (as indicated in the webinar acknowledgements). We may accept sponsorship for webinars to allow us to run competitions and maintain our ability to put on free meetings in high quality venues. Webinar sponsors get the opportunity of a short presentation at the beginning of the webinar, and we may disseminate some information through our mailing list after the event. Sponsorship does not represent endorsement by LPDG or its affiliates.
If you still have unanswered questions after reading this page, wish to present a talk, suggest a venue or sponsor a meeting, please contact us.
The organising committee is made up of early and "not-so-early" career scientists
from academia and industry.
If you are interested in joining the committee, please get in touch.
After my PhD in blood plasma cancer proteomics I moved to the Cancer Proteomics Group at UCL. I founded the LPDG as a focus group for the SE. I am currently at the Babraham Institute investigating protein degradation pathways using proteomics.
I am a post doc at ICL, developing mass spectrometry and data analysis methodology for the study of protein PTMs, in particular methylation. My research is multidisciplinary, using chemistry, bioinformatics and biology. For more info, click here.
I am a post-doc at the ICR in Paul Huang’s group. My research interest is in extracellular matrix remodelling during cancer progression. From an analytical point of view, I am interested in protein quantification by DIA mass spectrometry.
I manage an MS lab at QMUL. I graduated from Drexel University (USA) in Biomedical Science, completing my PhD work at Harvard University. After a long stint in the private sector, I re-joined academia here in the UK researching lipidomics and proteomics.
Danai studied biology and biomedical sciences in Greece. She has worked in numerous labs in England, Singapore, the Netherlands and Greece. Now she is focusing on her PhD at UCL in Primary Biliary Cholangitis analyzing human samples using Mass spectrometry.
I am a PhD student at UCL on the CellX project in the Thalassinos Lab studying competition in cellular populations using mass spectrometry-based proteomics.
Daniel is a post-doc in the lab of Prof. Ed Tate at Imperial College London. His research interests lie in the use of chemical proteomics for better understanding of drug targets, protein function, and post-translational modification dynamics.
Tom works for SCIEX in the London region helping customers with MS and 'OMICS applications. He gained an interest in MS from working with Prof Roy Goodacre, Manchester Institute of Biotech. applying -omics and chemometric approaches for rapid food authenticity determination.
Please email with any questions.
Particularly welcome are venue suggestions,
speaker suggestions or if you are thinking of sponsoring a meeting.
This seminar series is run by volunteers from academia and industry. We will try to reply to your email as quickly as possible, but please allow at least 5 days.
